My shop is in the back 1/3 of the basement. You have to go through the "man room" to get to it. You know a couch, a couple of chairs, big screen tv, drums and all the guitar stuff.
I made sure the walls are sealed at the floor and ceiling, the door has weather stripping on it and I have small dust collector. But the one thing that has kept the next room the cleanest are my shop shoes. Actually there just a pair of slip on sandels that never leave the shop. That way I don't track any sawdust out the door.
I get comfortable when I work in there.