Smooth Solo tone (in my world anyway)
Sey hello to your neck pickup and roll the tone down a bit.
If your using a very metal rythm sound an EQ pedal in the effects loop with a mid boost set into it is probably also not a bad idea.
Reverb, chorus and delay.... if you like.... I like a touch of chorus on everything...
Reverb is easy to overuse and muddy yourself, especially live, but it never fails to amaze me how much delay can be gotten away with...
Pedal vs Tube overdrive...
Well tubes are really better for this sort of thing... unless like me you use fender amps...
Both my ProCo Rat and H&K Warp Factor can produce smooth tones without a problem...