well i am not quite shure what he meant by boost the mids ... becasue yeah it would sound bad to me.. personally what i do for blues,rock stlyes is set my amp like so..
Bass 5-7
mids 5-7
treble 7-10
gain 5
vol - 5-6
with that on my strat i get a nice creamy sound running thru the amp alone (crate g600) this gives me a nice clean tone with just enough bite to respond to my picking dynamics ..a smooth picking stlye gives me nice and clean and if i pick a bit hard i get a nice on the edge sound and for a harder edge i just up the gain a lil
for a metal sound i use my digitech heavy metal distortion pedal
it has a knob to scoop the mids and whatnot it gives anywhere from randy roahds to old metallica, megadeath,pantera etc
and leave my amp settings alone
but i use my ibanez whene playing metal stlyes ..
just my $0.02 cents ..