I have fair sized hands, I can pick up a basketball with my left hand. I still have the guitar that I learned to play on 35 years ago, a 24" scale Musicmaster with an "A" neck (1.5" nut). As a result I learned to use my thumb on the bottom E. I normally use a .10 on the top and have no problem doing sweet and clear bends on the 22nd fret. Easy to use the whole fretboard.
I also have no problem switching between my 25.5" scale Jazzmaster, Strats, and Teles 21 & 22 fret necks. The longer scale does have more resonance and I don't use my thumb as much so just a slightly different technique is required. Of course a lot depends on your style but I find the shorter scale sounds punchier.
I think it's good to have both options.
I always go as narrow as possible. Nowadays that's pretty much a 1 5/8" nut.
That "A" neck is one of the nicest things I've ever held in my hand. If I could find one in the 25.5" scale I'd be the happiest man on earth.