As a general rule, I'm with Joobsauce on the single-coil in the neck, low-ish output humbucker in the bridge thing. I'm also big on P-90s.
Even more than that, I like actual magnetic pole-pieces a la Fender single-coils, but Strat pickups and the like are all too skinny for me.
Which is why my favorite pickup period is the Fender Jazzmaster pickup.