Here's my lineup: 1 Strat, 1 Parts (and building another), 1 Tele FMT, 1 Hamer. On gigs I take 2 or 3 of them, depending on how much I want to lug around But unless I break a string, I usually end up playing the Strat (or alternating sets with the Parts) all night.
On the other hand, the other guitar player in my band has more damn guitars than anyone I've ever seen (3 LPs, 1 PRS, 1 Hamer, 1 Steinberger, et al ad infinitum ad nauseam), and he'll sometimes change on almost every song.
Too much trouble, I say. I can approximate any sound he gets on all those buckers with my singles so I can concentrate on the song rather than the guitar.
So, subjectively anyway, the Strat wins hands down.