to say there are no pros to a single pup guitar is false, i think.
what about a les paul junior compared to a special?
same body, but the neck pup cuts through the neck tenon on the special, and they sound different.
it wouldnt be so significant on a bolt on neck guitar.
the electronics could be tailored to the specific pup, instead of a compromise between multiple pups.
also, playing wise, it the single pup scenario forces you to be creative with what youve got.
i personally like the idea of a single pup guitar and will be building a mahogany bodied, set neck esquire, once i get tooled up and ready.