Wow, Dave, that was quite an articulate post. I don't think I've written that well since college, if at all.
My 3axis machine should have no problem with this design. Of course, you have to use a little enginuity to keep the machine's limitations from becoming an issue. For instance, I'd first create index holes in the outer margins of the wood blank. Then, I can rout the cavities on the backside before turning the blank over and doing the front. On this, I'd probably cut out the shape last. There are no undercuts in this body, and in fact, if the body took more than 20 min. to program, I'd be suprised.
The neck would be cut separately. The only issue I see is in drilling the holes for the tuning pegs and cutting the shape of the headstock. I'd probably rough out the head and then make a jig to hold the headstock for drilling the holes and doing any inlay work, as well as one finishing pass on the shape to clean it up. Nothing too tricky. Again, you'd need a system of indexiing to be able to do both front and backside, although I'd probably surface-plane the blank before machining and use that surface for attaching the fingerboard.
There are several different CAM programs, with varying complexity to their use. The speed at which this design can be programmed for onsie-twosie production should be fairly fast, depending on the skill of the programmer and the strategy the software uses to determine the toolpaths. Probably the most time consuming aspect would be thinking about what kind of jig to use on the headstock. That's one of those things you think about early in the morning before you get out of bed.