When I first sit down by my amp to jam and pass the time, I like to start off with wicked distortion, compression, using the bridge pickup and after a bit of shredding, chugging, palm muting etc. I grow bored with that. I am playing thru my self built 335.
I then switch to a clean channel and often without any effects use the neck pickup and just noodle around playing jazz or blues type stuff. I find this a lot more invigorating and satisfying than the dirty stuff to be quite honest.
What are your preferences guys?