I have tried a lot of Seymour Duncans and DiMarzios.
I ended up installing DiMarzio Breeds in my strat. They are incredibly smooth, warm, with a nice pick click. They also tap really nice to get a hot single coil sound as well. I have a Tone Zone S in the middle slot but it is much more grainy sounding than the Breeds. The best way to discribe them is like a thicker, smoother, hotter, vintage PAF pickup with massive sustain. But they also clean right up when you back off the volume.