Now this is a hard vote to put just "one" guitarist at the top. For me my fav. guitarist is John Petrucci, Steve Vai,Joe Satriani,Eric Johnson,Greg Howe,Tony Mcalpine,Eddie VanHalen,Chris Degarmo,Yngwie Malmsteen,Marty Friedman, Alex Lifeson, SRV,Chris Isaak, Gary Hoey,Phil Keaggy, Lincoln Brewster,Bob Hartman....I could go on and on The thing is i cant just say "the best guitarist is.." Because to me, all these guys are #1 . most might sound simular to another yet each one has that uniqness about there playing and sound that will inspire me I love everything about the guitar and all those who have made it soooo exciting and inspiring for the rest of us. lol Everyones a winner !!!!!!!!