i'm going to add my two cents worth but first i have to say that i'm far from an expert. this is my first and only chambered or semi-hollow bodied build. and i built this entire guitar around the 1980 gibson t-bucker in the neck position. i wanted a blues/jazz sound and felt like the chambered body would help accomplish that. the body is walnut..not a wood known for it's mellow sound. the top is zebra wood. this piece was somewhat poreous. i left a solid stip 3.5" wide down the middle for the bridge and neck pocket then routed half way through (depth wise) between the pickups and below the bridge. i had an idea that a little air movement from one side to the other would help achieve the sound that i was looking for.
the bridge pickup is an overwound di marzio of questionable parentage and somehow this guitar came out sounding just exactly like i wanted it to..very low and mid range...bluesey/jazzy.
my point in all of this is that the end product..tone/volume/sustain, etc...is a result of many factors. pickups and how they're wired, body style, body wood density, neck wood and how it's attatched i suppose, nut material, type of bridge and probably some things that i'm forgetting.
i got lucky..well luck and a fair idea of what it should sound like. go ahead and make your guitar with the fun of making it in mind. drop some les paulish pups into it and i'll bet it will sound real close. and if not who knows? you may come up with a sound all your own.
good luck on your project