I would mix them for the reasons shown in the Crimson videos: If you apply alcohol based dye first, let's say like bright yellow, it won't blend to green if you apply water based blue stain over it. That's one way to get the Caribbean Sea effect on a flamed maple top. If you use water based dye for both you'll get a blotchy green. If you want to make a sunburst turning from black through red to yellow/amber, apply the yellow as alcohol based first all over, then the water based red where it needs to be, then water based yellow to the center smudging the edge of the red ring, then water based black to the outer ring, again smudging with the red. You can even do the blending from one colour to the other with a wet rag, using circular movements or swipes from one colour to the other. As you'll see in my thread, I very much redid the top today to get the burst smoother and the center lighter.
Yes, they can be "hot" but they're also noise cancelling by nature. On a single coil pickup the coil runs one direction only which will catch any electric noise like the hiss of fluorescent lights. On a humbucker there's two single coils wound in opposite directions which effectively makes the unwanted noise signals to counteract each other. The metal housing often used also creates sort of a Faraday cage to further cancel noise.