Very true but a les paul with a dimebucker wont exactly sound good if you know what i mean.
If you already know what will sound good, why are you asking?
If you have a sound in mind, that means you've already heard it. If you've already heard it, go to the source and see what that person uses. If you uses similar equipment, with a lot of practice, you might get close. More likely you'll end up sounding just like you.
By the way, in the right hands a Les Paul with a Dimebucker might surprise you. Like I said, it's not what you use but how you use it.