I remember talking to a Dimarzio rep about pickup placement and orientation and he basically told me that there is no "right" way to either mount a pickup, its position or its orientation (adjustable pole pieces).
We were talking about Zebra pickups and how I wanted to change the orientation so that I got the colors in the way I wanted to see them.
Basically, he told me that there's a traditional or "purist" was of orienting pickups and that it had nothing to do with sound "quality", at least not for the pickups I was going to use, or 99% of the pickups on the market today. For something like a Diamrzio SD - there is zero difference.
I think that you should try any pickup location you want and if it sounds good to you... it probably sounds good to others.
Actually, I think that depending on wood and pickup selection, you should try to place the pickups in slightly different places to attempt to get to the sound you want. For example, on my latest build, I put the bridge pickup closer to the bridge than I normally would because the top wood is soft and I wanted to get some brightness and edge out of the bridge pickup. Putting it too far away would lose some of that bite I like so much. You can also see than I set the adjustable pole pieces towards the neck - another non-traditional way of orienting pickups. I wanted the neck side to be closer to the strings while having the pickups closer for more bite. Does orientation make a difference? A slight difference and you can't notice it easily. Does the crowd notice when playing a show? No
Compare that to a Godin LGX and you'll see that the bridge pickup on the LGX is way far. Further out than a Les Paul. Result? A dull sounding guitar, even with a Dimarzio SD or EMG-81. The only reason why I keep that guitar is that it looks nice and has the LR Baggs bridge.