My interface is the Presonus Firepod into a rackmount PC with an array of 6 harddrives for storage and the OS is running on a 7th drive. Dual LCD monitors so I can spread my work across 2 displays. Playback through a set of Tannoy studio speakers. I am using Cubase SX3, I have Nuendo but havent even tried it yet. I usually mic my cabinet but I have Guitar rig2 that I like also, it has lots of options and you can build whatever rig you want.My studio desk