I would think not, because then any "special resonance" you get would only work for that note and other notes related closely in the overtone series. So if you "tuned" the guitar to the low E of standard tuning, you probably wouldn't get any extra resonance on, say, a 1st pos Dmaj chord starting on the D string. Yeah, of course pitches close to D and F# occur in E's overtone series. But the upper harmonics are so weak, I don't think this would affect them the way it might affect, say, the first two octaves of E's and B's. Now, if you tuned the guitar to low E and played a first pos. E chord (or better yet, the open E chord on the 7th fret A string), you'd probably get the extra resonance you seek.
The bigger trouble with this kind of thing is that people don't realize what a compromise you have on equal-tempered instruments. Technically only the octaves are in tune, which means that when you play that basic D chord, the F# on the thin E string is quite sharp of the F# that is ringing several octaves higher in your open D string.
So if this is going to be a comprehensive endeavor, you may need to build a guitar specifically for one key, then fret the guitar in such a way that it will play all notes in that key perfectly in tune. Make sure you never try to play it in another key, because that will sound bad. Better yet, remove the possibility by leaving blank fingerboard in place of inappropriate fret/string combinations. Build twelve such guitars, one for each half-step up the chromatic scale, and you'll be in business!