Hi,
I forget which model it is, but the Gibson custom shop makes a chambered LP. Also, Warmoth makes chambered bodies. In both cases, they discuss the impact on the sound.
Personally, I find that the biggest difference, in the case of Tele's, is that they are too body light and neck heavy. So I have to prop the neck up with my hand.
For more thoughts, do a search on this sight. There are numerous threads already existing.
Guitar Ed