I guess in the end it all comes down to preference. What do you enjoy playing? Set Neck, Through Neck or Bolt On.
I like neck through as they are comfortable in the upper ranges.
Set neck is good too and is easier to fret than neck through (i wouldn't fret a board unless it was on the neck, some people do though)
Bolt on is easier than set and through necks, also easily replaced if you screw up.