I put my vote in for Humbuckers, cause thats generally what I like for the majority of stuff I do, however when I want to clean up my sound, I really am of the opinion you cant beat the crisp sound of a single coil. I've played a lot of different guitars, but unfortunately i dont actually -own- guitars with a lot of the combinations I still want to try, like the dimebucker/jazz combo.
My fav humbuckers are ones ive only just discovered for myself recently, the Mastertone SPA (Super Phat Ass) and vHO (Vintage High Output) combo. They are active pickups, and as I understand it they are manufactured here in Australia. Ive been playing a les paul that has a set in it that belongs to a guy im housesitting for, and godamn, i love it Ive only had limited experience with EMG's, but these babies go hard! Still dont clean up as well as i'd like, but they have this raw edge to them that i love. Im not one of the people that thinks EMG's sound sterile, but there are people who think these are the missing link between passive and active pickups. Im not quite sure its like that, but I love these a bit more than the sound of EMG's, i think its just cause they are australian