I have a beard and had pretty good results with a full face respirator, (the riot looking kind) In fact today I machine sanded the bottom of a boat all day and was fine. That horrible blue stuff on the bottom I mean. The sander was just a few inches above my face and I didnt have any leaks. As far as fumes/vapors go, you may have to shave
Edit, just saw your post, I own that 3m respirator and I LOVE it. It makes a huge difference. I also have the organic vapor inserts as well as the particulate inserts on it, its still easy to breathe.