That would be the logical thing to do.
I've been running a preamp into the power section of a Lexicon Signature 284, cranked to 10. Thing is, when the MP-1 went down I had to go with the Lex by itself, and I was surprised to find that I got a much bigger, punchier, gutsier sound. (Not sure, but I think a regular head runs the preamp tubes at a higher plate voltage than most rackmount preamps.) Anyway, that got me thinking seriously about dumping the separate preamp scenario for a straight-up head.
Either way, I'll still run it like this: amp----> load box ----> f/x ----> clean power amp ----> speaker cab.