True Temperament frets only ensure that the guitar plays as close as practicable to Equal Temperament rather than each note being mathematically perfect (a physical impossibility on a guitar, or indeed any instrument where the notes are primarily developed by fixed means - piano, organ, harp etc). Even then, the TT fretted instrument will still have the same inherent pitch errors already present within the Equal Temperament system, something that cannot be avoided in western music.
I've seen many people say that bending strings on a TT guitar must feel weird, or require a different playing style. But the counter-argument by people who have tried it always appears to be that it feels no different...or perhaps they just adapt quickly?