Some interesting stuff here.
I've done countless mods, refrets, refinishes (ok ish but I lack patience), and assembled several guitars from combinations of new and old parts, but am just about to start on a complete build.
I think part of the answer really depends on how long you expect to wait before you can play your creation. If you want it in a month or two, get a kit or someone to build it for you.
If you're prepared to put months in and progress slowly and patiently, I don't think it's impossible that you can build something you're really proud of (at least that's my personal gamble).
But I think I can guarantee that if you do build one, kit or full custom job, it won't be your last.